In TFG-depleted islets, although the differences were not striking, being slightly or marginally significant, upregulation of Wee1 and downregulation of genes encoding enzymes in the pentose phosphate pathway (glucose-6-phosphate dehydrogenase X-linked, phosphogluconate dehydrogenase) were observed (Supplementary Fig.
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Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.
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