Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria.

without bacteremia ( P > 0.4 for all, data not shown). var transcript levels and associations with parasite biomass, sequestered parasite load, or endothelial activation in severe malaria In all children with severe malaria (children with CM, SMA, or CM/SMA), there was no correlation of transcript levels of any var gene group with parasite biomass or sequestered parasite biomass (Table 4 ). Among endothelial activation markers, the only comparison that reached close to significance was the association between transcript levels reported by the DBLa2/1.1/2/4/7 primers and sVCAM-1 levels in severe malaria ( P = 0.054, when adjusted for multiple comparisons, Table 4 ).

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