Computer simulation models of pre-diabetes populations: a systematic review protocol.

1 Cardiovascular disease, retinopathy, nephropathy and lower limb amputation are common diabetes-related complications and there is a highly significant association between glycaemic levels and the development of each of these complications. 2 Prediabetes, a condition characterised by intermediate hyperglycaemia, is associated with a high risk of developing diabetes. 3 According to the American Diabetes Association, prediabetes is defined as a fasting plasma glucose level of 100–125 mg/dL (known as impaired fasting glucose (IFG)), a 2-hour plasma glucose level after a 75 g oral glucose tolerance test of 140–199 mg/dL (known as impaired glucose tolerance (IGT)) or haemoglobin A1c (HbA1c) 5.7 to <6.5%.

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