ESE-1/ELF3 mRNA expression associates with poor survival outcomes in HER2⁺ breast cancer patients and is critical for tumorigenesis in HER2⁺ breast cancer cells.

Although there is a slight trend to activation of caspase 3/7 activity upon knock down of ESE-1 in both cell lines, the results were not statistically significant compared to the siScr control, indicating that ESE-1 KD does not induce apoptosis (Figure 4B ).

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