Omeprazole promotes carcinogenesis of fore-stomach in mice with co-stimulation of nitrosamine.

Oncotarget · 2017 · PMC5642558 · PMID 29050283

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a decreasing trendno p-value reported

Although overall there is a decreasing trend in incidence, the world is witnessing an increasing number of adenocarcinomas of the esophagogastric junction (EGJ) in recent decades [ 4 , 5 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.