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Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysis.

World J Gastroenterol · 2017 · PMC5643276 · PMID 29085200

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an increasing trendno p-value reported
difficile ) infection (CDI) has registered an increasing trend worldwide both in incidence and severity[ 1 - 5 ], with healthcare costs varying between 1.2 and 4.7 billion dollars each year in the United States alone[ 6 - 9 ].

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