TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.

Although the level of total tau was not different between hTau/ Trem2 +/+ and hTau; Trem2 −/− mice, there were highly significant increases in tau phosphorylation at Ser202/Thr205 (AT8; P < 0.01), Thr231 (AT180; P < 0.01), and Ser396/Ser404 (PHF-1; P < 0.01; Fig. 1a, b ) in the cortices, along with early pathogenic tau conformation specific epitope MC1 (Additional file 1 ).

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