CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases.

There was a strong and highly significant association between mean LN+ T-CTLA-4 and LN+ T-PD-L1 score ( r = 0.404, P < 0.001 ) , while there were no correlations with the stromal and tumor epithelial PT counterparts.

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High stromal CTLA-4 expression was associated with an independent positive outcome for the SCC subgroup, and showed a positive trend for all patients.

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