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The Toll-like receptor 4 antagonist TAK-242 protects against chronic pancreatitis in rats.

Mol Med Rep · 2017 · PMC5646963 · PMID 28765897

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an increasing trendno p-value reported
The overall incidence of chronic pancreatitis worldwide is approximately 2 to 200 per 100,000, and recent data indicate an increasing trend year by year ( 1 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.