Dual antiplatelet therapy for secondary prevention of coronary artery disease.

In the prespecified subgroup of patients with clinically evident ACVD (n=12 153), there was a marginally significant reduction in the primary ischaemic endpoint in the clopidogrel plus aspirin group (6.9% vs 7.9%, RR 0.88, 95% CI 0.77 to 0.998, p=0.046), whereas asymptomatic patients with multiple risk factors only (n=3284) assigned to clopidogrel plus aspirin experienced a 20% relative risk increase in the rate

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