Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial artemether-lumefantrine in African children.

Decreases of pharmacokinetic exposure [as estimated by AUC (AUC 0-8hr )] were marginally significant for artemether (by -46%, p = 0.08) and dihydroartemisinin (-22%, p = 0.06) in the children on nevirapine-based ART, compared to when artemether-lumefantrine was administered alone.

also in 26,082 other papers

NVP reduced AUC 0-8hr for both ARM and DHA by 68% (p<0.0001), and 28% (p = 0.02), respectively, but only led to a small trend toward increased LR exposure of 18% (p = 0.8) based on median AUC, the geometric mean AUC changes are -70%, -35%, and +3% for ARM, DHA, and LR, respectively[ 24 ].

also in 722 other papers