Optogenetic silencing of a corticotropin-releasing factor pathway from the central amygdala to the bed nucleus of the stria terminalis disrupts sustained fear.

There was a highly significant repeated measure effect of time bins, suggesting changes in freezing as the testing session progressed (F(5,12)=105.05, p<0.0001), but no between group difference (F(1,16=0.61, ns) nor interaction effects (F(5,12)=0.97, ns).

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The interaction effect was marginally significant, F(5,18)=2.27, p<0.091, with freezing during the third, fourth and fifth time bins (minutes 6–15) lower in the CRF-ArchT group (Holm’s sequential Bonferroni, bin 3: p<0.046, bin 4: p<0.008, bin 5: p<0.046.

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