Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: A combined analysis of two randomized controlled trials.

Interpretation This combined analysis of our two vitamin D RCTs showed a significant 26% reduced risk of the primary end-point asthma/recurrent wheeze during the first 3 years of life, which suggests that the non-significant/borderline significant trial responses observed in the individual intent-to-treat analyses were partly due to lack of power caused by an overestimation of the treatment effect, rather than lack of an intervention effect.

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