Patients Affected by Unmethylated O(6)-Methylguanine-DNA Methyltransferase Glioblastoma Undergoing Radiochemotherapy May Benefit from Moderately Dose-Escalated Radiotherapy.

Biomed Res Int · 2017 · PMC5660746 · PMID 29159183

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The MGMT promoter methylation positive status has a highly significant predictive role of response to TMZ combined with RT [ 1 , 5 ], whereas unmethylated MGM is considered an inherent prognostic indicator for patients with GB with a particularly poor survival [ 6 , 7 ].

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