In vivo study of doxorubicin-loaded cell-penetrating peptide-modified pH-sensitive liposomes: biocompatibility, bio-distribution, and pharmacodynamics in BALB/c nude mice bearing human breast tumors.

As shown in the body weight change curve ( Figure 4A ), the weight of CPPL(DOX) group of nude mice did not decline, but showed an increasing trend, whereas the weight of the nude mice in the PL(DOX) and NS groups decreased with the growth of tumor.

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Based on a single hemolysis experiment, although there was a little significant difference in hemolysis between CPPL(DOX) and PL(DOX) when phospholipid concentrations were <400 μmol/L ( Figure 1C ), CPPL(DOX) were considered nontoxic due to their low hemolysis (<10%).

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