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T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock Proteins.

Front Immunol · 2017 · PMC5662553 · PMID 29123529

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an increasing trendno p-value reported
The updated estimates of the incidence (20.04 per 100,000 per year) and prevalent cases (129,350) of T1D in children 0–14 years old in Europe for 2013 ( 46 ) reflect an increasing trend of 3–4% per annum during the past 20 years ( 47 ).

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