Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies.

Due to the small samples for each strain, increases in ischemic cortex P t O 2 only showed a weak trend when tested separately for SHRs (mean increase: 6.2 mmHg; t = 1.72, p = 0.16; n = 5) and Wistar rats (mean increase: 26.4 mmHg, t = 1.95, p = 0.15; n = 4).

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Consistent with the literature [ 46 , 58 – 60 ], the NBO regimen applied here did however result in significant increases in ischemic cortex P t O 2 across the two strains (i.e., pooled data)—although within strain these increases did not quite reach statistical significance, probably due to small samples and variable changes.

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