High-fat diet and chronic stress aggravate adrenal function abnormality induced by prenatal caffeine exposure in male offspring rats.

Sci Rep · 2017 · PMC5665976 · PMID 29093513

Europe PMC DOI

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0.0100

closest p · 0.2× alpha

0.0500

boldest claim

The sentences

a decreasing trendP < 0.01actually significant

Adrenal steroidal synthetase levels in the PCE group were significantly reduced or presented a decreasing trend under HFD condition, including the levels of StAR, CYP11A1, 3β-HSD and CYP11B1 ( P < 0.01).

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an increasing trendP < 0.05actually significant

The mRNA levels of all the IGF1 signal pathway components were increased or showed an increasing trend under HFD conditions, such as the levels for IGF1, IGF1R, AKT1 and steroidogenic factor 1 (SF1) ( P < 0.05, P < 0.01).

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