Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.

45 46 Specifically, Bauer and colleagues suggested a borderline significant inverse association for postmenopausal women with a relative risk per 12.5 nmol/L of circulating 25(OH)D of 0.97 (0.93 to 1.00). 45 We did not find an association between genetically determined 25(OH)D concentrations and risk of breast cancer, and our study was powered to find minimum detectable odds ratios ranging from 0.84 to 0.87 per 25 nmol/L in 25(OH)D.

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We found a marginally significant association for total prostate cancer, for which a genetically determined 25 nmol/L increase in 25(OH)D concentration yielded an odds ratio of 0.89 (95% confidence interval 0.77 to 1.02; P=0.08; fig 3).

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