Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux.

Neither the individual cohorts nor the UK/Slovenian combined cohort achieve the HLOD of 3.3 that would most probably be required to conclude ‘significant’ linkage 31 (allowing for the fact that the LOD score has been maximized over two models–recessive and dominant–as well as over a heterogeneity parameter α , the proportion of linked families) but the results are certainly consistent with the much stronger (and highly significant) effect seen here when all three cohorts are combined.

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