Provided that an important part of the monomer of insulin is located at the hexamer-forming surface of the molecule [ 24 ], a highly significant fraction of the polyclonal antibodies against monomeric insulin used in the insulin immunoassay techniques are most likely incapable of recognizing the antigenic form of hexameric Zn 2+ -insulin.
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Zn2+ chelation by serum albumin improves hexameric Zn2+-insulin dissociation into monomers after exocytosis.
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