Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation.

Oncotarget · 2017 · PMC5669887 · PMID 29137261

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a decreasing trendno p-value reported

On the other hand, following Nutlin-3-induced IGF-1R down-regulation the levels of ERK1/2 phosphorylation in DFB and BE cell lines, demonstrated a decreasing trend over time following ligand stimulation, revealing an early but short-lived biased MAPK signaling.

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