Induction of Broad-Spectrum Protective Immunity against Disparate <i>Cryptococcus</i> Serotypes.

We also observed an overall trend toward significantly increased proinflammatory cytokine (IL-1α, IL-1β, and IL-17A), immunoregulatory cytokine (G-CSF), and chemokine (CCL3, CCL4, CCL2, CXCL1, and CCL5) production as early as day 3 post challenge that remained elevated through day 7 post challenge in H99γ immunized mice challenged with each serotype compared to similarly challenged mice immunized using HKH99γ (Tables 2 and 3 ).

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