Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer.

Int J Oncol · 2017 · PMC5673027 · PMID 29075787

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highly significantno p-value reported

The ability of 2,3-DHBA and 2,5-DHBA to inhibit CDK1 activity is highly significant, because they are known to be generated from salicylic acid metabolism through CYP450-mediated reactions ( 11 ).

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