highly significantP < 0.001
The PR diet produced an even greater and highly significant LeR increase from baseline and compared to the control diet in neuronal‐enriched EVs (interaction of diet type and time point, F(1, 36) = 20.120, P < 0.001; univariate post hoc comparison of the two diets after 1 month, F(1, 43) = 6.41, P = 0.015; univariate post hoc comparison between baseline and 1 month after PR diet, F(1, 35) = 52.772, P < 0.001) (Fig. 2 B).