highly significantp-value < 0.0001
Significant increment was shown at 8.5 minutes of exercise in volunteers and patients in group A, but not in group C. Change-in-angle scores There was a highly significant effect of exercise stage on the change-in-angle scores (p-value < 0.0001) adjusting for groups; mean change in angle scores at 2.5 min, 5.5 min and 8.5 min were 44.9, 63.8 and 79.0, respectively.