Trafficking and processing of bacterial proteins by mammalian cells: Insights from chondroitinase ABC.

Addition of the 3’UTR to the ChABC cDNA resulted in highly significant growth cone targeting (P<0.001, n = 106 growth cones) of the enzyme.

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It may be significant that both these proteins are significantly smaller than ChABC, 219 and 396 amino acids respectively compared to 1026 amino acids of ChABC, and are thus likely to undergo folding more easily.

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