A prospective randomized controlled study: Theophylline on oxidative stress and steroid sensitivity in chronic obstructive pulmonary disease patients.

Mortality statistics for COPD show an increasing trend with increase in age and also smoking increases mortality in COPD patients.[ 4 ] Many risk factors contribute to the development of COPD, these factors include environmental issues (humidity, dust, hot weather, very cold weather, etc.,) genetic susceptibility, age >40 years, gender, nutrition, socioeconomic status, oxidative stress, occupational hazards, cigarette smoking, fuel fumes, and many others.[ 5 ] Alveolar macrophages present in lungs produce histone deacetylase (HDAC) which suppresses the production of cytokines that mediate inflammation.

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