Interleukin-1β signaling in fenestrated capillaries is sufficient to trigger sickness responses in mice.

Analysis of endothelial nuclear NF-κB revealed a highly significant effect of genotype (total number of NF-κB+ nuclei surrounded by Cd31 IR: Myd88 fl/fl = 92.33 ± 13.68, Tek Δ Myd88 = 3.333 ± 2.404, and Slco1c1 Δ Myd88 = 0.3333 ± 0.3333, mean ± SEM; genotype F (2, 6) = 42.47, p = 0.0003, n = 3 for all).

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