Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.

Although the change in RQ, although highly significant, appears to be small it is physiologically important as it is not because of a short-term change, for example, a short burst of exercise, but is a more sustained effect, already present immediately post-weaning of Casp2 −/− mice, which is likely to have long-term physiological outcomes.

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