Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells.

Oncotarget · 2017 · PMC5685692 · PMID 29163771

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of borderline significanceno p-value reported

It was previously shown that high HOXA9 expression was associated with a poor outcome in this malignancy [ 2 ], although in the larger cohort examined here this relationship was only of borderline significance.

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borderline significanceno p-value reported

This revealed that a number of HOX genes were significantly related to survival in AML, including HOXA5 ( p = 0.03), HOXB2 ( p = 0.002), HOXB4 ( p = 0.037), HOXB9 ( p = 0.001), and HOXC9 ( p = 0.007) (Figure 1 ), whilst HOXA4 ( p = 0.067) and HOXA9 ( p = 0.06) showed borderline significance.

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