In WT autapses, baclofen induced a marked, persistent and highly significant facilitation in response to the second pulse with a significant increase in the paired-pulse ratio (PPR), while CGP55845 in the presence of GABA significantly decreased PPR.
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Impaired GABA<sub>B</sub>-mediated presynaptic inhibition increases excitatory strength and alters short-term plasticity in synapsin knockout mice.
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