Preconceptual Zika virus asymptomatic infection protects against secondary prenatal infection.

ZIKV-specific IgG levels were sharply increased in nearly all concepti homogenates of pregnant mice with prior preconceptual infection compared with the concepti of naive control mice, with a highly significant inverse correlation with ZIKV RNA levels amongst individual concepti scattered across multiple litters with low level breakthrough infection ( Fig 4D ).

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