Barely Significant
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Comparing proton treatment plans of pediatric brain tumors in two pencil beam scanning nozzles with different spot sizes.

J Appl Clin Med Phys · 2015 · PMC5690992 · PMID 26699553

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may not be significantno p-value reported
Finally, while the reduction of mean and maximal dose may not be significant enough to impact vision or hearing loss, doses of this level can affect IQ development and the rate of secondary cancers; (17) this is why proton therapy is felt to be particularly beneficial in the pediatric population.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.