These findings are highly significant as they reveal an oxidative stress-sensitive FOXO-PRDX1 signaling pathway that calibrates FOXO responses in tumor suppression and aging toward the regulated expression of genetic and epigenetic factors when PRDX1 detects increased cellular peroxide levels.
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A Peroxidase Peroxiredoxin 1-Specific Redox Regulation of the Novel FOXO3 microRNA Target let-7.
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