LncRNA H19 is a major mediator of doxorubicin chemoresistance in breast cancer cells through a cullin4A-MDR1 pathway.

In China, an increasing trend in mortality is observed for 3 of the 10 most common cancers (breast, cervix, and ovary), while it tends to be stable for others such as colorectal, lung, uterine, and thyroid cancers [ 2 , 3 ].

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