As for the search of the ideal conditions of radio-enhancement, only effects of incident protons have been simulated, and there is no indication of a possible trend of the track structure effect, thus emphasizing an ion type dependence (beyond pure LET), as has been demonstrated for the RBE (Friedrich et al. 2013 ).
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Particle therapy and nanomedicine: state of art and research perspectives.
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In addition, the role of oxygenation of the medium (quantified by the Oxygen Enhancement Ratio—OER) may be significant.