Barely Significant
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A systematic review of discomfort due to toe or ear clipping in laboratory rodents.

Lab Anim · 2017 · PMC5700778 · PMID 28429644

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borderline significantno p-value reported
17 When re-analyzing the primary data from included studies as SMD or RR, we found five additional significant effects of toe clipping, namely: increased vocalization, reduced motor activity and toe swelling after clipping on PND7 in mice, impaired adult swimming ability in rats clipped on PND4 (all Figure 5 ), as well as a borderline significant decrease in post-weaning body weight for female pups clipped on PND7 ( Figure 4 ).

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