Scoring Targets of Transcription in Bacteria Rather than Focusing on Individual Binding Sites.

Consequently, the main general advantage of AD method, which is its large sensitivity, becomes a weakness in this application, as small differences with respect to the null distribution (that may also arise from its approximate nature), are (conveniently) not captured by KS, but are classified as statistically highly significant by AD test, leading to low AD specificity (a large number of false positives).

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The most likely reason is that the randomized regions do not capture (possibly significant) negative selection that acts on σ 70 binding sites.

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