Variables that influence BRAF mutation probability: A next-generation sequencing, non-interventional investigation of BRAFV600 mutation status in melanoma.

PLoS One · 2017 · PMC5703505 · PMID 29176861

Europe PMC DOI

hedged sentences

0.0532

closest p · 1.1× alpha

0.1419

boldest claim

The sentences

borderline significancep = 0.0532so close (0.05 < p ≤ 0.1)

Analysis of the different BRAFV600 mutation types (n = 249) found that BRAFV600E was significantly influenced by center (p = 0.0020) and gender (p = 0.0386), while location of sample had borderline significance (p = 0.0532).

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a statistical trendp = 0.1419not close (p > 0.1)

A main effects MLR model identified age (p = 0.0001), center (p = 0.0004), and melanoma subtype (p = 0.014) as significantly influencing BRAFV600 mutation probability; ultraviolet (UV) exposure showed a statistical trend (p = 0.1419).

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