a trend towards significancep = 0.09
A repeated measures ANOVA revealed that no changes in the in vivo optical signal was found in the control animals ( p = 0.32), however, there was a significant change during the same observation time in the low and moderate rHDL NP concentration-dosed animals ( p < 0.002) and a trend towards significance in animals administered a high concentration of rHDL NPs ( p = 0.09).