Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation.

EBioMedicine · 2017 · PMC5704088 · PMID 29050947

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Though with highly significant implications in autoimmune diseases, the molecular mechanisms for controlling Th17 and Treg cell divergence remain not well understood. cAMP response element binding protein (CREB) is one of the best characterized phosphorylation-activated transcription factors in the basic leucine zipper (bZIP) superfamily, comprising of CREB, ATF1 and CREM.

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