The Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) study demonstrated that the reduction in Lp-PLA2 activity during the first year of treatment was a highly significant predictor of coronary heart disease events, independent of any change in LDL-C, and may account for over half of the benefits of pravastatin ( 16 ).
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Comparison of the effect of rosuvastatin versus rosuvastatin/ezetimibe on markers of inflammation in patients with acute myocardial infarction.
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