α7 nAChR mediated Fas demethylation contributes to prenatal nicotine exposure-induced programmed thymocyte apoptosis in mice.

Oncotarget · 2017 · PMC5706832 · PMID 29212186

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a decreasing trendP = 0.06so close (0.05 < p ≤ 0.1)

As shown in Table 1 although the average methylation rates of the Fas promoter were not changed after nicotine treatment, among those CpG sites, nt +295, −2394, and −2441 showed significantly decreased frequency of single CpG methylation after nicotine treatment ( P < 0.05), and the methylation level on nt +456 also showed a decreasing trend ( P = 0.06).

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