The Systemic Response to Topical Aldara Treatment is Mediated Through Direct TLR7 Stimulation as Imiquimod Enters the Circulation.

Sci Rep · 2017 · PMC5707416 · PMID 29185473

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failed to reach significanceno p-value reported

Interestingly, Il1b and Tnfa failed to reach significance despite an upward trend and Il10 was only significantly higher at 12 hours after treatment.

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