In FcγRIIB -/- yaa mice, the activity index has highly significant correlations with IEM-evaluated glomerular disease features, proteinuria and anti-dsDNA antibody titer We used correlation analysis to identify the strongest factors having impact on lupus nephritis progression in FcγRIIB -/- yaa.
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Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.
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