APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing.

Using Fisher's exact test (Fisher, 1922 ) on the number of genes with statistically significantly increased/decreased expression vs genes with nonsignificant changes in expression, we obtain a P ‐value of 10 −16 , a highly significant result.

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