Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

Upon UV-uncaging in cells loaded with cg-PI(4,5)P 2 we found a small, but highly significant increase of EGFP fluorescence at the cell’s footprint in line with the liberation of PI(4,5)P 2 at the plasma membrane, while no such effect was observed in control cells, which were also subjected to UV-light, but not loaded with cg-PI(4,5)P 2 ( Figure 2c ).

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