Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium.

There was a highly significant correlation between log 2 -transformed expression ratios where transplanted HIOs and adult epithelium shared enriched genes while HIO and fetal epithelium shared enriched genes (p=2.6 × 10 -28 ).

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This may be significant, as Mucin 5AC is not specific to the goblet cell but is widely expressed by the small intestinal enterocytes.

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