A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression.

Nucleic Acids Res · 2017 · PMC5716207 · PMID 29059299

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highly significantno p-value reported

To test whether as expected the antisense genes would regulate each other resulting in this highly significant inverse correlation, we employed antisense oligonucleotides and RNAi to study transcript-dependent effects as well as dCas9-based transcriptional modulation by CRISPRi/CRISPRa for transcription-dependent effects.

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